A select overview of our technology and accomplishments

Todd R. McNutt, John P. Gibbons, and Binbin Wu, “Knowledge-Based Treatment Planning”, Khan’s Treatment Planning in Radiation Oncology Fifth Edition, Sperduto, Paul W., and John P. Gibbons, 722, Philadelphia, PA, Wolters Kluwer, 2022. ISBN/ISSN: 9781975162016

Scott Robertson, D Lasher, B Kassas, “Dose Predictions Facilitate Efficient Optimization of High-Quality Prostate Treatment Plans“, American Association of Medical Physicists, Annual Meeting 2022

Scott P. Robertson, Todd R. McNutt, “Evaluation of OAR Sparing in Prostate Radiotherapy Plans Optimized with Database Dose Predictions“, American Association of Medical Dosimetrist, Annual Meeting 2022

Peijin Han, Russell Hales, Pranav Lakshminarayanan, Zhi Cheng, Christen Elledge, Alex Negron, Sarah Hazell, Chen Hu, Cole Friedes, Lori Anderson, Jeffrey Hoff, Kristen Marrone, Harry Quon, Todd McNutt, K Ranh Voong, “Exploring the Relationship of Radiation Dose Exposed to the Length of Esophagus and Weight Loss in Patients with Lung Cancer,” Practical Radiation Oncology. 3/19/2020

Yue Guo W Jiang, P Lakshminarayanan, P Han, Z Cheng, M Bowers, X Hui, I Shpitser, S Siddiqui, RH. Taylor PhD, H Quon, T McNutt, “Spatial radiation dose influence on xerostomia recovery and its comparison to acute incidence in head neck cancer patients,” Advances in Radiation Oncology, 2020, 5(2), pp. 221-230

Todd McNutt PhD, Kevin L. Moore PhD, Binbin Wu, PhD, Jean L. Wright1 MD, “Use of big data for quality assurance in radiation therapy,” Seminars in Radiation Oncology, Jan 2019

Han, P. Lakshminarayanan, W. Jiang, I. Shpitser, X. Hui, MD, S H Lee, Z Cheng, Y Guo, RH. Taylor, SA. Siddiqui, M Bowers, K Sheikh, A Kiess, BR. Page, J Lee, H Quon, TR. McNutt, “Dose/volume histogram Patterns in salivary gland subvolumes influence xerostomia injury and recovery,” Nature – Scientific Reports, Volume 9, Issue 1, 1 December 2019, Article number 3616

Sheikh, K., Lee, S.H., Cheng, Z., Lakshminarayanan, P., Peng, L., Han, P., McNutt, T.R., Quon, H., Lee, J, “Predicting acute radiation induced xerostomia in head and neck Cancer using MR and CT Radiomics of parotid and submandibular glands,” Radiation Oncology, Volume 14, Issue 1, 29 July 2019, Article number 131

Lakshminarayanan, W. Jiang, S. Robertson, Z. Cheng, P. Han, M. Bowers, J. Moore, I. Shpitser, S. Siddiqui, RH Taylor, H. Quon, T.R. McNutt, “Radio-morphology: Parametric Shape-Based Features in Radiotherapy,” Medical Physics, Volume 46, Issue 2, Februaryy 2019, Pages 704-713

Jiang, P. Lakshminarayanan, X. Hui, P. Han, Z. Cheng, M. Bowers, I Shpitser, S. Siddiqui, R.H. Taylor, H. Quon, T. McNutt, “Machine learning methods uncover radio-morphologic dose patterns in salivary glands that predict xerostomia in head and neck cancer patients,” Advances in Radiation Oncology, Volume 4, Issue 2, April – June 2019, Pages 401-412

Zhi Cheng, Lauren M Rosati, Linda Chen, Omar Y Mian, Yilin Cao, Marta Villafania, Minoru Nakatsugawa, Joseph A Moore, Scott P Robertson, Juan Jackson, Amy Hacker-Prietz, Jin He, Christopher L Wolfgang, Matthew J Weiss, Joseph M Herman, Amol K Narang, Todd R McNutt, “Improving prediction of surgical resectability over current staging guidelines in patients with pancreatic cancer who receive stereotactic body radiation therapy,” Advances in Radiation Oncology vol 3 iss. 4, pp 601-610, 10/1/2018

Zhi Cheng, Minoru Nakatsugawa, Xian Chong Zhou, Chen Hu, Stephen Greco, Ana Kiess, Brandi Page, Sara Alcorn, John Haller, Kazuki Utsunomiya, Shinya Sugiyama, Wei Fu, John Wong, Junghoon Lee, Todd McNutt, Harry Quon; “The Utility of Clinical Decision Support System (CDSS) in Weight Loss Prediction following Head and Neck Cancer Radiotherapy;” JCO Clinical Cancer Informatics 2019:3, 1-11

Feng, Z, Rao, AD, Cheng, Z, Shin, EJ, Moore, J, Su, L, Kim, S-H, Wong, J, Narang, A, Herman, JM,,McNutt, T, Li, D, Ding, K; Dose Prediction Model for Duodenum Sparing With a Biodegradable Hydrogel Spacer for Pancreatic Cancer Radiation Therapy; International Journal of Radiation Oncology Biology Physics Volume 102, Issue 3, 1 November 2018, Pages 651-659

Minoru Nakatsugawa, Zhi Cheng, Ana Kiess, Amanda Choflet, Michael Bowers, Kazuki Utsunomiya, Shinya Sugiyama, John Wong, Harry Quon, Todd McNutt; The Needs and Benefits of Continuous Model Updates on the Accuracy of RT-induced Toxicity Prediction Models within a Learning Health System; International Journal of Radiation Oncology* Biology* Physics 10/6/2018

Zhi Cheng, Lauren M Rosati, Linda Chen, Omar Y Mian, Yilin Cao, Marta Villafania, Minoru Nakatsugawa, Joseph A Moore, Scott P Robertson, Juan Jackson, Amy Hacker-Prietz, Jin He, Christopher L Wolfgang, Matthew J Weiss, Joseph M Herman, Amol K Narang, Todd R McNutt; Improving prediction of surgical resectability over current staging guidelines in patients with pancreatic cancer who receive stereotactic body radiation therapy; Advances in Radiation Oncology vol 3 iss. 4, pp 601-610, 10/1/2018

Luke C Peng, Xuan Hui, Zhi Cheng, Michael R Bowers, Joseph Moore, Emilie Cecil, Amanda Choflet, Alex Thompson, Mariah Muse, Ana P Kiess, Brandi R Page, Christine G Gourin, Carole Fakhry, Michal Szczesniak, Julia Maclean, Peter Wu, Ian Cook, Todd R McNutt, Harry Quon; Prospective evaluation of patient reported swallow function with the Functional Assessment of Cancer Therapy (FACT), MD Anderson Dysphagia Inventory (MDADI) and the Sydney Swallow Questionnaire (SSQ) in head and neck cancer patients; Oral Oncology, Vol. 84, p 25-30, 9/1/2018

Cheng, Zhi, Nakatsugawa, Minoru, Hu, Chen, Robertson, Scott P., Hui, Xuan, Moore, Joseph A., Bowers, Michael R., Kiess, Ana P., Page, Brandi R., Burns, Laura, Muse, Mariah, Choflet, Amanda, Sakaue, Kousuke, Sugiyama, Shinya, Utsunomiya, Kazuki, Wong, John W., McNutt, Todd R., Quon, Harry; Evaluation of classification and regression tree (CART) model in weight loss prediction following head and neck cancer radiotherapy; Advances in Radiation Oncology, Volume 3, Issue 3, July–September 2018, Pages 346-355

Veeraj P Shah, Pranav Lakshminarayanan, Joseph Moore, Phuoc T Tran, Harry Quon, Curtiland Deville, Todd R McNutt; Data integrity systems for organ contours in radiation therapy planning; Journal of applied clinical medical physics, 6/12/2018 – online before publication

McNutt, SH. Benedict, DA Low, K Moore, I Shpitser, W Jiang, P Lakshminarayanan, Z Cheng, P Han, Xuan Hui, M Nakatsugawa, J Lee, JA. Moore, SP. Robertson, V Shah, R Taylor, H Quon, J Wong, T DeWeese; Using Big Data Analytics to Advance Precision Radiation Oncology; Int J Radiation Oncol Biol Phys, June 1, 2018, Volume 101, Issue 2, Pages 285–291

John Wong, Todd McNutt, Harry Quon, Theodore L DeWeese; Big Data Applications in Radiation Oncology; CRC Press, Advanced and Emerging Technologies in Radiation Oncology Physics, 5pg Chapter 14, ed. Siyong Kim and John Wong 353, 5/24/2018

Todd R McNutt, Michael Bowers, Sierra Cheng, Peijin Han, Xuan Hui, Joseph Moore, Scott Robertson, Charles Mayo, Ranh Voong, Harry Quon; Practical data collection and extraction for Big Data applications in radiotherapy; Medical Physics, 2/15/2018

Harry Quon, Xuan Hui, Zhi Cheng, Scott Robertson, Luke Peng, Michael Bowers, Joseph Moore, Amanda Choflet, Alex Thompson, Mariah Muse, Ana Kiess, Brandi Page, Carole Fakhry, Christine Gourin, Jolyne O’Hare, Peter Graham, Michal Szczesniak, Julia Maclean, Ian Cook, Todd McNutt; “Quantitative Evaluation of Head and Neck Cancer Treatment–Related Dysphagia in the Development of a Personalized Treatment Deintensification Paradigm;” International Journal of Radiation Oncology*Biology*Physics Volume 99, Issue 5, 1 December 2017, Pages 1271-1278

Chen R, Gabriel P, Kavanagh B, McNutt; How will big data impact clinical decision making and precision medicine in radiation therapy?; Int’l J. of Radiation Oncology, Biology, Physics. Published online: November 27 2015

McNutt T., Moore K., Quon H; “Needs and Challenges for Big Data in Radiation Oncology;” Int’l J. of Radiation Oncology, Biology, Physics. Published online: November 27 2015. Print: July 1, 2016 Volume 95, Issue 3, Pages 909–915

Marungo F, Robertson S, Quon H, Rhee J, Paisley H, Taylor R, McNutt T; Creating a Data Science Platform for Developing Complication Risk Models for Personalized Treatment Planning in Radiation Oncology; 48th Hawaii International Conference on System Sciences (HICSS). Kauai, HI USA: IEEE; 2015

Robertson S, Moore J, Cheng S, Quon H, McNutt T; A Data-Mining Framework for Large Scale Analysis of Dose-Outcome Relationships in a Database of Irradiated Head and Neck (HN) Cancer Patients; Medical Physics 42(7), 4329 (7/2015) (Editor’s Pick 2015)

Wu B, Pang D, Lei S, Gatti J, Tong M, McNutt T, Kole T, Dritschilo A, Collins S; Improved robotic stereotactic body radiation therapy plan quality and planning efficacy for organ-confined prostate cancer utilizing overlap-volume histogram-driven planning methodology; Radiother Oncol. 2014 Aug 6. pii: S0167-8140(14)00304-1. doi: 10.1016/j.radonc.2014.07.009

Heather M Starmer, Wuyang Yang, Raju Raval, Christine G Gourin, Marian Richardson, Rachit Kumar, Bronwyn Jones, Todd McNutt, Sierra Cheng, Harry Quon; Effect of Gabapentin on Swallowing During and After Chemoradiation for Oropharyngeal Squamous Cell Cancer; Dysphagia, June 2014, Volume 29, Issue 3, pp 396–402

Moore KL, Kagadis GC, McNutt TR, Moiseenko V, Mutic S; Vision 20/20: Automation and advanced computing in clinical radiation oncology; Med Phys. 2014 Jan;41(1)

W Y Yang, J Moore, H Quon, K Evans, A Sharabi, J Herman, A Hacker-Prietz and T McNutt; Browser Based Platform in Maintaining Clinical Activities – Use of The iPads in Head and Neck Clinics; Phys.: Conf. Ser. 489 012095 doi:10.1088/1742-6596/489/1/012095 Int’t Confernce on Computers in Radiotherapy, Melbourne AUS 2013

Moore, J.A., Evans, K., Yang, W., Herman, J., McNutt, T., “Automatic treatment planning implementation using a database of previously treated patients,” (2014) Journal of Physics: Conference Series, 489 (1)

Rachit Kumar, Sara Madanikia, Heather Starmer, Wuyang Yang, Emi Murano, Sara Alcorn, Todd McNutt, Yi Le, Harry Quon; Radiation dose to the floor of mouth muscles predicts swallowing complications following chemoradiation in oropharyngeal squamous cell carcinoma; Oral Oncology Volume 50, Issue 1, January 2014, Pages 65-70

Yibing Wang, Andras Zolnay, Luca Incrocci, Hans Joosten, Todd McNutt, Ben Heijmen, Steven Petit; A quality control model that uses PTV-rectal distances to predict the lowest achievable rectum dose, improves IMRT planning for patients with prostate cancer; Radiotherapy and Oncology Volume 107, Issue 3, June 2013, Pages 352-357

Wu, D. Pang, P. Simari, R. Taylor, G. Sanguineti, T. McNutt; Using overlap volume histogram and IMRT plan data to guide and automate VMAT planning: a head-and-neck case study; Medical Physics. Medical Physics 02/2013; 40(2):021714

Yidong Yang, Eric C Ford, Binbin Wu, Michael Pinkawa, Baukelien van Triest, Patrick Campbell, Danny Y Song, Todd R McNutt; An overlap-volume-histogram based method for rectal dose prediction and automated treatment planning in the external beam prostate radiotherapy following hydrogel injection; Medical Physics 01/2013; 40(1):011709

Steven F. Petit, Binbin Wu, Michael Kazhdan , André Dekker, Patricio Simari, Rachit Kumar, Russel Taylor, Joseph M. Herman, Todd McNutt; Increased organ sparing using shape-based treatment plan optimization for intensity modulated radiation therapy of pancreatic adenocarcinoma; Radiotherapy and Oncology, Volume 102, Issue 1, January 2012, Pages 38-44

Binbin Wu, Todd McNutt, Marianna Zahurak, Patricio Simari, Dalong Pang, Russell Taylor, Giuseppe Sanguineti; Fully Automated Simultaneous Integrated Boosted-Intensity Modulated Radiation Therapy Treatment Planning Is Feasible for Head-and-Neck Cancer: A Prospective Clinical Study; International Journal of Radiation Oncology, Biology, Physics, Volume 84, Issue 5, 1 December 2012, Pages e647-e653

Wu, B., Ricchetti, F., Sanguineti, G., Kazhdan, M., Simari, P., Jacques, R., Taylor, R., McNutt, T.; Data-driven approach to generating achievable dose-volume histogram objectives in intensity modulated radiotherapy planning; International Journal of Radiation Oncology, Biology, Physics 2011 Mar 15;79(4):1241-7. Epub 2010 Aug

Simari P, Wu B, Jacques R, King A, McNutt T, Taylor R, Kazhdan M.; A statistical approach for achievable dose querying in IMRT planning; Med Image Comput Comput Assist Interv. 2010;13(Pt 3):521-8.

Patricio Simari, Binbin Wu, Robert Jacques, Alex King, Todd McNutt, Russell Taylor, and Michael Kazhdan; A Statistical Approach for Achievable Dose Querying in IMRT Planning; Medical Image Computing and Computer-Assisted Intervention 5762/2009(12), 100–108 (2009)

Binbin Wu, Francesco Ricchetti, Giuseppe Sanguineti, Misha Kazhdan, Patricio Simari, Ming Chuang, Russell Taylor, Robert Jacques, Todd McNutt; Patient Geometry-Driven Information Retrieval for IMRT Treatment Plan Quality Control; Medical Physics, 2009 Dec;36(12):5497-505

Michael Kazhdan, Patricio Simari, Todd McNutt, Binbin Wu, Robert Jacques, Ming Chuang, and Russell Taylor, “A Shape Relationship Descriptor for RadiationTherapy Planning” Medical Image Computing and Computer-Assisted Intervention 5762/2009(12), 100–108 (2009)

McNutt T, Wong J, Purdy J, Valicenti R, DeWeese T. OncoSpace: A New Paradigm for Clinical Research and Decision Support in Radiation Oncology Proceedings of the XVIth International Conference on the Use of Computers in Radiation Therapy, Amsterdam, 2010, Editor Jan-Jakob Sonke, Published by Het Nederlands Kanker Instituut – Antoni van Leeuwenhoek Ziekenhuis ISBN: 978-90-75575-29-3